Skeletal-related events (SREs) are associated with increased mortality in men with bone metastatic castration-resistant prostate cancer (mCRPC), according to study findings published online in Prostate Cancer and Prostatic Diseases.

The study, by Lauren E. Howard, MD, of Duke University School of Medicine in Durham, North Carolina, and colleagues, included 233 men with nonmetastatic castration-resistant prostate cancer who later progressed to bone metastases. During follow-up, SREs occurred in 88 patients (38%) and 198 (85%) died. SREs were associated with a 67% increased mortality risk, after adjusting for age, race, biopsy Gleason score, primary treatment to the prostate, PSA, and other covariates. the researchers reported. After adjusting for bone pain, SREs were associated with a 42% increased risk.

The researchers noted that SREs, including pathologic fracture, spinal cord compression, radiation and surgery to bone, are common in bone mCRPC patients.

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