ORLANDO—Men with PSA values of 1.5-4 ng/mL have a significantly elevated four-year risk of being diagnosed with prostate cancer compared with men who have PSA levels below 1.5, according to a retrospective study of 21,502 men.
The study, by E. David Crawford, MD, of the University of Colorado Health Sciences Center in Aurora, and Judd W. Moul, MD, of the Duke Prostate Center at Duke University in Durham, N.C., found that 7.9% of men with baseline PSA values of 1.5-4 were diagnosed with prostate cancer after four years compared with 0.5% of men with a baseline PSA below 1.5, the researchers reported here at the American Society of Clinical Oncology annual meeting.
After controlling for race and age, men with a baseline PSA of 1.5-4 had a 12 times greater risk of being diagnosed with prostate cancer over four years than men with a baseline PSA below 1.5. The risk was 17 times greater among African Americans.
At baseline, the study population had a mean age of 55 years and mean PSA level of 1.