Only pathologic staging is independently associated with biochemical recurrence-free survival (BCRFS) following radical prostatectomy (RP) for prostate cancer, according to the findings of a study conducted in Thailand.
Virote Chalieopanyarwong, MD, and colleagues at Prince of Songkla University in Songkha, Thailand, enrolled 178 men with a mean age of 68.2 years who underwent RP. Of these, 93 patients had high-risk disease based on the D’Amico risk classification criteria. The median follow-up was 32.5 months and the median time to biochemical recurrence (BCR) was 22.3 months. The 5-year BCRFS rates were 79.8%, 79.9%, 69.9%, 35.6%, and 26.8% among patients with Gleason score 6, 3+4, 4+3, 8, and 9–10 (corresponding to Gleason grade groups 1–5), respectively, the investigators reported in the Asian Pacific Journal of Cancer Prevention (2017;18:2555-2559). On multivariable analysis, only pathologic stage T3a and T3b were independently associated with BCRFS; patients with these stages had 8.45 and 7.1 times increased risks for BCR, respectively, compared with those who had pathologic stage T2a. The researchers defined BCR as 2 consecutive rising PSA values greater than 0.2 ng/mL.
The authors noted that Thailand does not have an established policy for prostate cancer screening, so many cases presented with advanced disease.
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Reference
Chalieopanyarwong V, Attawettayanon W,Kanchanawanichkul W, and Pripatnanont C. The prognostic factors of biochemical recurrence-free survival following radical prostatectomy. Asian Pac J Cancer Prev. 2017;18:2555-2559.
