High stress levels are associated with an increased rate of prostate cancer (PCa)-specific mortality among men treated for clinically localized PCa, according to researchers.

Michael Jan, MD, and collaborators at the Karolinska Institutet in Stockholm, Sweden, surveyed 4,105 men treated for clinically localized prostate tumors. Those with the highest levels of perceived stress had a 66% increased risk of PCa-specific mortality compared with men who had low stress levels, the investigators reported online ahead of print in the Scandinavian Journal of Urology. They also had a high frequency of grieving and sleep loss, as well as fewer people with whom to share their emotional problems, according to the investigators.

“This study contributes to the growing field of psychosocial quality of life research in men with prostate cancer…  The findings of this study could prove useful to target interventions to improve quality of life in men with prostate cancer,” the authors concluded.