Obese patients with prostate cancer (PCa) are more likely to experience worse outcomes after radical prostatectomy (RP), a new study suggests.
Investigators at Seoul National University Bundang Hospital in Seongnam, Korea, studied 2997 PCa patients who underwent RP from 2006 to 2017. They stratified patients into 3 body mass index (BMI) groups according to World Health Organization recommendations for Asian men: normal weight (less than 23 kg/m2), overweight (at least 23 but less than 27 kg/m2), and obese (27.5 kg/m2 or higher).
In multivariate analysis, obese patients had significant 1.27-fold increased odds of biochemical recurrence and 2.3-fold increased odds of cancer-specific mortality compared with normal weight patients after adjusting for PSA level, diabetes mellitus, pathologic Gleason score and other clinicopathologic factors, Young Dong Yu, MD, and colleagues reported in Scientific Reports.
Final pathologic findings showed that obese patients had significantly higher rates of positive surgical margins than overweight and normal weight patients (13.9% vs 2.6% vs 1.4%, respectively), extraprostatic invasion (19.9% vs 15.6% vs 11.1%), pathologic Gleason score of 8 or higher (50.8% vs 38.5% vs 30%), and lymph node invasion (14.5% vs 14.3% vs 10.6%) compared with overweight and normal weight patients.
Yu YD, Byun SS, Lee SE, Hong SK. Impact of body mass index on oncological outcomes of prostate cancer patients after radical prostatectomy. Sci Rep. 2018;8:11962.