Metabolic factors are not associated with the risk of prostate cancer (PCa), but higher body mass index (BMI) and systolic blood pressure increase the risk of PCa-related death, according to findings published online in Cancer.

Christel Häggström, MSc, of Umeå University Hospital in Sweden, and colleagues examined the correlation between metabolic factors and the risk of prostate cancer and death from prostate cancer using data for 289,866 men in the Metabolic Syndrome and Cancer Project. The separate and combined effects of metabolic factors were assessed.

During a mean follow-up of 12 years, the researchers identified 6,673 men diagnosed with PCa and 961 PCa-related deaths. The researchers found a non-significant decrease in the risk of PCa among men with high levels of glucose and triglycerides for the top versus the bottom quintile. However, compared with patients in the bottom quintile of BMI, those in the top quintile had a significant 36% increased risk of PCa-related death. Elevated systolic blood pressure was associated with a significant 62% increased risk.

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“In conclusion, high levels of body mass index, blood pressure, blood glucose, triglycerides, cholesterol, and a combination of these factors were not found to be associated with an increased risk of prostate cancer,” the investigators wrote. “In contrast, high levels of body mass index, blood pressure, and a combination of metabolic factors were associated with a modest increase in the risk of prostate cancer death.”