Lower serum total testosterone prior to radical prostatectomy (RP) for prostate cancer is associated with lymph node metastases, according to a study.

Austrian researchers led by Christian Kratzik, MD, of the Medical University of Vienna, analyzed preoperative levels of serum total testosterone of 217 patients undergoing RP for possible associations with Gleason score (6 or less vs. 7 vs. 8-10) and tumor stage (pT2 vs. pT3 vs. N+). Patients with a PSA level above 10 ng/mL and Gleason scores of 7 or higher were submitted to standard lymphadenectomy.

Significantly lower levels of total testosterone were found in men with nodal meastases than in patients with non-metastatic disease, the researchers reported in Anticancer Research (2011;31:3615-3618). They observed no association between testosterone, Gleason score, and stage in patients with non-metastatic disease.

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