Lower PSA and shorter PSA doubling times prior to salvage radiotherapy (RT) for prostate cancer after primary radical prostatectomy are associated with favorable biochemical outcomes, according to researchers.

Ohseong Kwon, MD, and collaborators at Seoul National University Bundang Hospital in Seongnam, Korea, reviewed the records of 212 PCa patients who underwent salvage RT because they experienced biochemical recurrence (BCR) after primary radical prostatectomy.

The overall median follow-up was 63.5 months. The 5-year BCR-free survival rate was 58.2% for the cohort overall and 76.2% for the 118 patients (55.7%) who had early salvage RT, defined as RT started when the PSA level was 0.5 ng/mL or less, the investigators reported online in PLoS One (2014;9(7):e103574).

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Results showed that a pre-RT PSA level of 5 ng/mL or less, a pre-RT PSA doubling time greater than 4.5 months, positive surgical margins, and androgen deprivation therapy concomitant with salvage RT independently predicted favorable biochemical outcomes.

“We believe that our findings would contribute to the selection of appropriate candidates and optimize the outcome of salvage RT,” the authors concluded.