Regular irbesartan use after nerve-sparing radical retropubic prostatectomy (RRP) could improve postoperative recovery of erectile function among patients with normal preoperative erectile function, according to researchers.

Investigators led by Arthur L. Burnett, MD, of Johns Hopkins Hospital in Baltimore, studied 17 men who underwent RRP and who started daily oral irbesartan 300 mg on postoperative day 1. All were potent prior to surgery. The researchers compared these men with a clinically matched group of 12 men who declined irbesartan use (controls). They evaluated erectile function using International Index of Erectile Function-5 (IIEF-5) questionnaires before surgery and at three and 12 months after surgery.

In addition, stretched penile length (SPL) was measured immediately and three months after surgery. While IIEF-5 scores at 24 months after surgery were statistically similar between the two groups, at 12 months the IIEF-5 scores of the irbesartan group were significantly higher than those of the control arm, the investigators reported online ahead of print in BJU International. The proportional loss of SPL after surgery was significantly less in the irbesartan than the control group at three months.

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