HealthDay News — For men with low-risk prostate cancer, factors such as ethnicity influence patient decision to pursue active treatment during active surveillance, according to a study published online in The Journal of Urology.
Scott P. Kelly, PhD, from the Georgetown University Medical Center in Washington, DC, and colleagues conducted a retrospective study involving 2,228 men diagnosed with low-risk prostate cancer who did not receive treatment within the first year of diagnosis. Factors associated with time from diagnosis to active treatment were examined.
The researchers found that 27% of the men began active treatment at a median of 2.9 years during follow-up. Compared with non-Hispanic white men, non-Hispanic black men were marginally more likely to begin active treatment, independent of baseline and follow-up clinical measures (hazard ratio [HR], 1.3; 95% confidence interval [CI], 1.0 to 1.7). Among those who remained on observation, rebiopsy within 24 months of diagnosis occurred at a slightly lower rate for non-Hispanic black than non-Hispanic white men (HR, 0.70; 95% CI, 0.60 to 1.0). Independent of race, Gleason grade progression (HR, 3.3; 95% CI, 2.7 to 4.1) and prostate-specific antigen doubling time less than 48 months (HR, 2.9; 95% CI, 2.3 to 3.7) correlated with active treatment initiation.
“Sociodemographic factors such as ethnicity and education may independently influence the patient decision to pursue active treatment and serial biopsies during active surveillance,” the authors write.
- Kelly SP, Van Den Eeden SK, Hoffman RM, et al. Sociodemographic and Clinical Predictors of Switching to Active Treatment among a Large, Ethnically Diverse Cohort of Men with Low Risk Prostate Cancer on Observational Management. J Urology. 2016; doi: 10.1016/j.juro.2016.04.045
- Dall’Era MA. Reasons for Abandonment of Active Surveillance in Men with Prostate Cancer. J Urology. 2016; doi: 10.1016/j.juro.2016.06.078