Higher flavonoid consumption is associated with reduced likelihood of aggressive prostate cancer (PCa), according to a study presented at the American Association for Cancer Research’s International Conference on Frontiers in Cancer Prevention Research in Anaheim, Calif.

Researchers at the University of South Carolina in Columbia, and colleagues analyzed data from 920 African-American (AA) and 977 European-American (EA) newly-diagnosed prostate cancer patients. A modified version of the National Cancer Institute Diet History Questionnaire was used to assess diet, and the intake of five subclasses of flavonoids was estimated.

Compared with the lowest tertile, the highest tertile of total flavonoid intake was associated with a 25% decreased odds of aggressive prostate cancer, after adjusting for age, race, education, smoking status, and screening history. With increasing flavonoid intake, the odds of aggressiveness prostate cancer were further reduced by age and smoking. The middle and highest tertiles were associated with a 38% and 33% decreased risk of aggressive PCa, respectively, among men younger than 65 years, and a 75% and 52% decreased risk among current smokers. The researchers observed no difference in the results based on race.

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“We found that higher total flavonoid intake was associated with reduced odds for aggressive prostate cancer in both African-American and European-American men, but no individual subclass of flavonoids appeared to be protective independently,” said investigator Susan E. Steck, PhD, MPH, RD, Associate Professor at the Arnold School of Public Health at the University of South Carolina in Columbia.