PSA Density Plus MRI May Improve Detection of Clinically Significant Prostate Cancer
Combining PSA density with prostate MRI findings improves the predictive performance of PI-RADS in men without a prior prostate cancer diagnosis.
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Prostate Cancer
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4Kscore May Help Predict Adverse Pathology at Radical Prostatectomy
In a study, a higher 4Kscore was significantly associated with a 16% greater risk of biochemical recurrence of prostate cancer following radical prostatectomy. -
Metformin Found Not to Prevent Prostate Cancer
A study looking at the effect of genetic variations on the pharmacologic activity of metformin found that use of the drug was associated with an increased risk of prostate cancer overall and of high-grade prostate cancer. -
SABR Found to Improve Outcomes in Recurrent Oligometastatic HSPC
In patients with recurrent oligometastatic hormone-sensitive prostate cancer, stereotactic ablative radiation therapy decreased the risk of disease progression compared with observation alone, a phase 2 study found. -
Genomic Alterations Linked to Outcomes in mCSPC
DNA sequencing in men with metastatic castration-sensitive prostate cancer revealed alterations in certain signaling pathways that predict worse overall survival and shorter progression time to castration-resistant disease. -
Prostate Cancer Immunotherapy Alone Is Not Enough
So far, prostate cancer immunotherapy has shown only modest benefits. To greatly improve outcomes, immunotherapy will need to be combined with other treatments, according to the authors of a recent review.
Latest Prostate Cancer News
Upfront Radiation May Be a Cost-Effective Strategy in Oligorecurrent Hormone-Sensitive Prostate Cancer
Upfront metastasis-directed therapy may be a viable treatment approach in patients with oligorecurrent disease, particularly those who wish to defer systemic therapy.
Routine Use of Neoadjuvant Docetaxel Plus ADT Not Supported in Localized, High-Risk Prostate Cancer
Patients with localized prostate cancer characterized by high-risk features are at increased risk of a negative outcome following radical prostatectomy.
GPS Assay Could Help Guide Treatment Decisions in Unfavorable, Intermediate-Risk Prostate Cancer
Men with GPS scores greater than 40 had a poor disease prognosis after surgery and their disease was likely to behave like that of high-risk patients.
Positive PSMA PET/CT at Biochemical Recurrence Predicts PCa Progression
In a study, a positive PSMA PET/CT scan was associated with a significant 4.5-fold higher adjusted risk for disease progression.
Inflammatory Markers Predict Prostate Cancer Risk
Men in the highest tertile of high-sensitivity C-reactive protein level had a 30% increased risk for prostate cancer compared with those in the lowest tertile in adjusted analyses.
ONS Releases Guidelines on the Management of Cancer Treatment–Related Hot Flashes
One objective underlying development of these guidelines was to identify research gaps regarding the management of cancer treatment–related hot flashes.
Real-World Effects of Prostate Cancer Treatment on Quality of Life Reported
First patient-driven study of the impact of various prostate cancer treatments documents differences in the effects of radical prostatectomy, radiation therapy, and chemotherapy.
Sarcopenia Ups Risk of Sexual Dysfunction After Nerve-Sparing RARP
Sarcopenia prior to nerve-sparing robot-assisted radical prostatectomy is significantly associated with sexual dysfunction after the surgery, according to investigators.
Older Age Predicts Erectile Dysfunction After Transperineal Prostate Biopsy
Increased age was significantly associated with increased odds of a decline in Sexual Health Inventory for Men category, a study found.
Multimodality Treatment vs ADT Alone for Oligometastatic PCa Tied to Better Outcomes
Lower rates of cancer-specific mortality and castration-resistant disease observed when patients received multimodality treatment compared with ADT alone.
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