Nocturnal polyuria is common among both men and women in the United States, according to new study findings presented during the 36th annual European Association of Urology virtual congress.

In the Epidemiology of Nocturnal Polyuria (EpiNP) study (NCT 04125186), 10,190 individuals aged 30 years and older and broadly representative of the US population (75% White; 14.5% Hispanic; 11.8% Black; 5.7% Asian) completed an online survey. Of these respondents, 3339 reported 2 or more nocturia voids on the lower urinary tract symptoms (LUTS) survey questionnaire. In the second phase, 1766 respondents also completed a bladder diary for 3 days. Using information from the bladder diaries, investigators calculated raw prevalence rates for the US general population.

Using the Nocturnal Polyuria Index (NPI33) threshold of more than 0.33, nocturnal polyuria was present in 39.1% of men and 49.9% of women, Karin S. Coyne, PhD, MPH, vice president of Patient-Centered Research at Evidera in Bethesda, Maryland, reported on behalf of her team. Using nocturnal urine production of greater than 90 mL/h (NUP90) as a definition, nocturnal polyuria was present in 31.6% of men and 25.7% of women.

Continue Reading

The investigators also examined subgroups of nocturnal polyuria using the NPI33 definition. Pure nocturnal polyuria with no underlying cause was more prevalent among women than men (13% vs 5.5%) and was highest in the 30-44 age group (14.6% and 6.5%, respectively), Dr Coyne reported. Idiopathic nocturnal polyuria was slightly more prevalent in younger age groups. Other causes of nocturnal polyuria — such as nocturnal polyuria with comorbid diabetes, hypertension, heart disease, or sleep apnea — generally increased with age.

Nocturnal polyuria with possible bladder outlet obstruction, defined as an International Prostate Symptom Score (IPSS) of 13 or higher, was the most common subtype among men using the NPI33 definition. Nocturnal polyuria with urgency symptoms suggestive of overactive bladder was most common among women.

When the investigators examined subgroups of nocturnal polyuria using the NUP90 definition, overall patterns remained the same by sex and age. 

According to Dr Coyne, these study findings highlight the importance of not only considering the multifactorial causes of nocturnal polyuria, but better understanding the prevalence of nocturnal polyuria by sex.

Disclosure: Some study authors declared affiliations with biotech, pharmaceutical, and/or device companies. Please see the original reference for a full list of authors’ disclosures. 


Coyne KS, Bosch JL, Chapple CR, et al. The prevalence of nocturnal polyuria in the US: Results from the Epidemiology of Nocturnal Polyuria (EpiNP) study. Presented at the EAU 2021 virtual conference, July 8-12, 2021. Abstract P0013.