Higher levels of an oxidative stress biomarker have been found in men and women with nocturia, researchers reported in BJU International.

In an observational study, Shingo Hatakeyama, MD, of Hirosaki University Graduate School of Medicine in Japan, and collaborators examined several indicators of oxidative stress and their relationship with lower urinary tracts symptoms (LUTS) in 1113 men and women in the Iwaki Health Promotion Project of 2015. They assessed LUTS using the International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS) questionnaires.

Advanced glycation end products (AGEs) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels were significantly higher in people with severe LUTS. Following multivariate logistic regression analyses, however, only AGEs were significantly associated with nocturia (more than 1 void nightly). AGEs had no relationship with IPSS and OABSS results.

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Whether rising levels of AGEs, measured by skin autofluorescence in the forearm, contribute to nocturia or vice versa remains an open question. Previous research has linked AGEs with diabetes, renal failure, vascular complications, and coronary heart disease, according to the study authors.

“Considering that nocturia has been reported to be associated with several health-related disorders, our observation supports the negative effect of deteriorated general health status via oxidative stress on nocturia,” Dr Hatakeyama and colleagues stated.

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Matsumoto T, Hatakeyama S, Imai A, et al. The relationship between oxidative stress and lower urinary tract symptoms: Results from the community health survey in Japan. BJU Intl. DOI:10.1111/bju.14535. (Article manuscript published online Sept 14, 2018)