Bladder hydrodistention with fulguration of Hunner lesions offers potential as a treatment for nocturia in patients with interstitial cystitis, according to investigators.

Atsushi Otsuka, MD, and colleagues at Hamamatsu University School of Medicine in Hamamatsu, Japan, reviewed the records of 81 patients with IC. Patients had a mean age of 62.2 years. They found significant differences in nocturia between Hunner- and non-Hunner-type IC. 

Nocturia was positively associated with age, urgency score based on the Interstitial Cystitis Symptom Index and a visual analogue scale, the nocturnal polyuria (NP) index, and mean number of urgency episodes over a 24-hour period, the investigators reported online in Lower Urinary Tract Symptoms. Nocturia was negatively associated with average voided volume.

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Age, average voided volume, NP index, and presence of Hunner lesions were independent factors associated with nocturia, according to the investigators. Bladder hydrodistention significantly decreased nocturia in patients without NP who had non-Hunner type IC.

In Hunner-type IC, bladder hydrodistention with fulguration of Hunner lesions significantly decreased nocturia regardless of the presence or absence of NP.


Otsuka A, Suzuki T, Aki R, et al. Clinical characteristics of self-reported nocturia in patients with interstitial cystitis, and effects of bladder hydrodistention (with fulguration of Hunner lesions) on nocturia. Low Urin Tract Symptoms. 2018; published online ahead of print.