Moderate nocturia may increase the risk of death among men aged 60 years and older, according to study. Among younger men, it may increase the likelihood of developing coronary heart disease (CHD) later in life.

In a study of 2,447 men in Olmsted County, Minnesota, followed for a median of 17.1 years, researchers led by Jennifer St. Sauver, PhD, of Mayo Clinic in Rochester, Minn., found that among men aged 60 years and older, those with moderate nocturia had a significant 48% increased risk of dying compared with those who did not have moderate nocturia, after adjusting for age, body mass index (BMI), use of urological medications, and CHD.

Among men younger than 60, subjects with moderate nocturia had a 68% increased risk of CHD later in life, although the associate was no longer significant after adjusting for age, BMI, and the use of urological medications.

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The researchers, who published their findings online ahead of print in BJU International, defined moderate nocturia as waking to urinate two or more times per night. For the study, they followed subjects every two years through repeated questionnaires and community medical records to determine the development of diabetes mellitus and hypertension as well as the occurrence of death. They ascertained CHD through ongoing surveillance of heart disease in Olmsted County.

Dr. St. Sauver’s team found no significant association between moderate nocturia and the later development of diabetes mellitus or hypertension.