Vitamin D supplementation increased the risk of hypercalcemia and hypercalciuria but did not increase the risk of kidney stones.
Long-term vitamin D supplementation does not increase the risk of kidney stones, according to a new systematic review and meta-analysis published online ahead of print in the American Journal of Clinical Nutrition.
Robert Scragg, MBBS, PhD, and colleagues at the University of Auckland in New Zealand analyzed the adverse effects related to calcium metabolism—hypercalcemia, hypercalciuria, and kidney stones—in 48 randomized controlled trials in which participants were given vitamin D supplements or placebo for 24 weeks or more. Vitamin D supplementation increased the risk of hypercalcemia and hypercalciuria by 54% and 64%, respectively, but did not increase the risk of kidney stones.
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