Diabetes, hypertension, frequent UTIs, the formation of struvite stones, and allopurinol use may predict the development of CKD among individuals who have had kidney stones, researchers reported in the American Journal of Kidney Diseases (2009; published online ahead of print).

John C. Lieske, MD, of Mayo Clinic in Rochester, Minn., and his colleagues studied 159 patients who presented at the clinic with kidney stones—53 who developed CKD (cases) and 106 who did not (controls). Controls were matched for age, gender, and date of the first kidney stone. The study population had a mean age of 57 years at the time of the first stone event. The investigators identified CKD cases using diagnostic codes.

Cases were significantly more likely than controls to have a history of diabetes (41.5% vs. 17%), hypertension (71.7% vs. 49.1%), UTIs (22.6% vs. 6.6%), struvite stones (7.5% vs. 0%), and allopurinol use (32.1% vs. 4.7%).

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