Higher serum uric acid level is modestly and independently associated with an elevated risk for development of nephrolithiasis in a dose-dependent manner in apparently healthy men, but not women, researchers in South Korea reported.

Seolhye Kim, MD, MSc, of Sungkyunkwan University School of Medicine in Seoul, and colleagues studied 239,331 Korean adults who underwent a health checkup examination from January 2002 to December 2014 and were followed up through December 2014.

Nephrolithiasis developed in 18,777 participants during 1,184,654 person-years of follow-up, for an incidence rate of 1.6 per 100 person-years, the investigators reported online ahead of print in the American Journal of Kidney Diseases.

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Among men, compared with patients who had baseline uric acid levels below 6.0 mg/dL, those with levels of 6.0–6.9, 7.0–7.9, 8.0–8.9, 9.0–9.9, and 10.0 mg/dL or more, had a 6%, 11%, 21%, 31%, and 72% increased risk of nephrolithiasis, respectively, in multivariable analysis.

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