Dyslipidemia is independently associated with an increased risk of kidney stones, researchers reported online ahead of print in The Journal of Urology.
Fabio Cesar Miranda Torricelli, MD, and colleagues at Cleveland Clinic retrospectively studied 2,442 patients with kidney stone disease who had a 24-hour urine analysis and lipid profile evaluation within three months of each other. After controlling for potential confounder such as age, gender, body mass index, diabetes, and hypertension, patients with high total cholesterol (TC) levels had significantly higher urinary potassium and calcium levels.
Patients with low HDL or high triglyceride (TG) levels had significantly higher urinary sodium, oxalate, and uric acid levels, and lower urinary pH. High TC and TG levels were significantly associated with a higher uric acid stone rate.