Doxazosin significantly improves expulsion of distal ureteral stones, according to researchers in Pakistan.
Investigators at Aga Khan University in Karachi randomly assigned 65 patients with a symptomatic 4-7 mm distal ureteral stone to receive only diclofenac sodium 50 mg for pain (controls, 32 patients) or both diclofenac 50 mg plus doxazosin 2 mg daily (33 patients). Treatment duration was until stone expulsion or 28 days, which came first. The groups were similar with respect to demographic, clinical, and stone-related parameters.
The stone expulsion rate was 38% for the control group compared with 70% for the doxazosin group, a significant difference between the treatment arms, the researchers reported in Urology (published online ahead of print). The doxazosin group also had a significantly shorter expulsion time. The researchers also observed significantly decreased pain episodes and analgesic use in the doxazosin-treated patients.
In a previous study of patients with distal ureteral stones published in the Journal of Endourology (2007;21:538-541), researchers also found that patients treated with doxazosin had significantly earlier expulsion of their stones compared with patients not treated with the drug. The study showed that the efficacy of doxazosin was significantly better for 5-10 mm stones than for smaller ones.