Alfuzosin is safe and effective for use as medical expulsive therapy for ureteral stones less than 10 mm in diameter, according to the findings of a systematicreview and meta-analysis published online in PLoS One.

Chenli Liu, MD, and colleagues at The First Affiliated Hospital of GuangzhouMedical University in Guangdong, China, analyzed data from 9 studies that metthe study’s selection criteria. These studies included 291 patients who receivedalfuzosin 10 mg, 134 who received tamsulosin 0.4 mg, and 280 who received conservativetherapy (controls). 

Compared with controls, alfuzosin-treated patientshad a significant 85% increased likelihood of becoming stone-free and a significant4 day shorter expulsion time. Stone-free rate and expulsion time did notdiffer significantly between alfuzosin and tamsulosin. Both drugs had similarcomplication rates. Pooled analysis showed a significantly lower frequency of retrogradeejaculation in the alfuzosin group than the tamsulosin group.