Patients with localized renal cell carcinoma (RCC) are more likely to have clear-cell rather than non-clear-cell RCC if they have a greater visceral fat area (VFA), according to a study.

Hong-Kai Wang, MD, of Fudan University Shanghai Cancer Center in Shanghai, China, and colleagues studied 487 patients with localized RCC and who had complete computed tomography and magnetic resonance imaging information available. A single-slice CT image was used to measure the area of visceral and subcutaneous adipose tissues. Of the 487 patients, 418 had clear-cell and 69 had non-clear-cell RCC.

The study cohort overall had a mean VFA of 102 cm2 and a mean body mass index (BMI) of 24 kg/m2.

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Results showed that the mean VFA was 25 cm2 greater in the clear-cell than the non-clear-cell patients. On multivariate analysis, VFA was important than the effects of BMI and type 2 diabetes for predicting histologic subtype, the investigators reported online ahead of print in BJU International. In patients with a normal BMI, those in a higher quartile of VFA were more likely to harbor clear-cell RCC than patients with in lower quartile.