Two proteins excreted in the urine appear to be sensitive and specific biomarkers of renal cancers of proximal tubule origin, possibly allowing for early screening for the disease.

Evan D. Kharasch, MD, PhD, and co-investigators at Washington University School of Medicine in St. Louis, Mo., found large amounts of the aquaporin-1 and adipophilin proteins in urine samples of kidney cancer patients.

Urine concentrations of these proteins were significantly greater in patients with clear cell or papillary cancers than in patients with renal cancer of nonproximal tubule origin, control surgical patients, or healthy volunteers, according to an online report in Mayo Clinic Proceedings.

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