Kidney function is preserved similarly whether patients with a benign oncocytoma receive partial nephrectomy (PN) or undergo active surveillance (AS), new study findings suggest.
Investigators reviewed data from 114 patients with a single oncocytoma confirmed via biopsy or surgical pathology who were managed with PN or AS during 2000-2020 at the Fox Chase Cancer Center in Philadelphia, Pennsylvania. Tumor diameter at baseline was similar between groups: 2.9 vs 2.8 cm, respectively. The 32 patients who elected AS were significantly older than the 82 who chose PN (median age: 72 vs 65 years). The AS group also had significantly lower baseline kidney function: median estimated glomerular filtration rate (eGFR) was 71 vs 82 mL/min/1.73 m2. The median follow-up duration was shorter for the PN vs AS group (21 vs 44 months).
In prediction models, longitudinal eGFR decline and probability of progression to chronic kidney disease stage 3 or higher did not differ significantly between groups, Kevin B. Ginsburg, MD, MS, of Fox Chase Cancer Center, and colleagues reported in Urologic Oncology. Due to the small sample size, the investigators could not adjust for patient comorbidities.
According to Dr Ginsburg’s team, “active surveillance for patients with oncocytomas delivers both safety and renal function preservation. The decision for intervention should be individualized and employed cautiously.”
Ginsburg KB, Strother M, Schober JP, et al. No difference in renal function outcomes for patients with oncocytoma managed with active surveillance vs. partial nephrectomy. Published online December 30, 2022. Urol Oncol. doi:10.1016/j.urolonc.2022.09.019