(HealthDay News) — For patients with obesity undergoing bariatric surgery, losing at least 20 to 35% of total body weight is associated with a more than 50% reduction in the risk for cancer, according to a study presented at the annual meeting of the American Society for Metabolic and Bariatric Surgery and The Obesity Society (ObesityWeek), held from Nov. 3 to 7 in Las Vegas.

Andrea Stroud, MD, from Oregon Health & Science University in Portland, and colleagues examined the correlation for surgical weight loss and changes in serum biomarkers with incident cancer in a cohort of 2353 patients undergoing bariatric surgery.

The researchers found that 82 patients reported a new cancer diagnosis during 8759 person-years of follow-up (936 per 100,000 person-years; 95% confidence interval, 749 to 1,156); 55 cancers were thought to be linked with obesity. The risk for cancer was lower for achieving a body mass index (BMI) <30 kg/m² (hazard ratio, 0.59; 95% confidence interval, 0.34 to 1.00) and for losing at least 20 to 34.9% of total body weight (versus <20%: hazard ratio, 0.44; 95% confidence interval, 0.25 to 0.76). An increased risk for incident cancer was seen with baseline BMI ≥50 kg/m² versus BMI <40 kg/m² (hazard ratio, 1.40; 95%  confidence interval, 0.68 to 2.86). The investigators also observed a decreased cancer risk associated with postoperative levels of glucose, proinsulin, insulin, and leptin.

“Our data suggests that there is a weight-loss threshold, that if achieved, significantly reduces risk of cancer in postbariatric surgery patients,” Stroud said in a statement.

Reference

Molitch ME, Gao X, Bebu I, et al. Early Glomerular Hyperfiltration and Long-Term Kidney Outcomes in Type 1 Diabetes: The DCCT/EDIC Experience. Clin J Am Soc Nephrol. June 2019, 14 (6) 854-861. doi:10.2215/CJN.14831218

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