(HealthDay News) — Once-daily enoxaparin is associated with fewer major bleeds than enoxaparin twice daily in patients with acute venous thromboembolism (VTE), according to a study published online in the Journal of Thrombosis and Haemostasis.

Javier Trujillo-Santos, MD, PhD, from the Hospital General Universitario Santa Lucía in Murcia, Spain, and colleagues assessed data from the RIETE registry for 4730 patients receiving enoxaparin: 3786 and 944 received enoxaparin twice and once daily, respectively.

The researchers found that, compared with those receiving enoxaparin twice daily, once-daily enoxaparin correlated with a trend toward more VTE recurrences (odds ratio [OR], 1.79; 95% confidence interval [CI], 0.55 to 5.88), fewer major bleeds (OR, 0.42; 95% CI, 0.17 to 1.08), and fewer deaths (OR, 0.32; 95% CI, 0.13 to 0.78) during the first 15 days. Patients on enoxaparin once daily had more VTE recurrences (OR, 2.5; 95% CI, 1.03 to 5.88), fewer major bleeds (OR, 0.40; 95% CI, 0.17 to 0.94), and fewer deaths (OR, 0.58; 95% CI, 0.33 to 1.00) at day 30. On propensity analysis, patients on enoxaparin once daily had fewer bleeds at 15 and 30 days (hazard ratios, 0.30 [95% CI, 0.10 to 0.88] and 0.16 [95% CI, 0.04 to 0.68]) and fewer deaths at 15 and 30 days (hazard ratios, 0.37 [95% CI, 0.14 to 0.99] and 0.19 [95% CI, 0.07 to 0.54]).

“Enoxaparin prescribed once daily results in fewer major bleeds than enoxaparin twice daily,” the authors write.

The RIETE registry was supported by Sanofi Spain and Bayer Pharma AG.

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  1. Trujillo-Santos J, Bergmann JF, Cristiano B, et al. Once- versus twice daily enoxaparin for the initial treatment of acute venous thromboembolism. J Thromb Haemost. 25 January 2017. doi: 10.1111/jth.13616