Heat shock protein 105 (Hsp105), a protein overexpressed in a variety of cancers, may be a novel prognostic indicator in patients who have undergone radical cystectomy for muscle-invasive bladder cancer (MIBC), researchers reported.

In a study of bladder cancer samples from 84 patients, Japanese investigators found that high expression of Hsp105 is independently associated with favorable cancer-specific survival (CSS), according to findings published in Molecular and Clinical Oncology (2014;2:38-42). The 5-year CSS for patients was 73.3% for patients with high Hsp105 scores versus 46.9% for those with low Hsp105 scores. CSS was twice as likely among patients with a high hsp105 score as those with a low score. Hsp105 score did not correlate with age, nuclear grade, or pathologic tumor stage.

“The expression of Hsp105 may provide a novel prognostic marker in bladder cancer and enable the selection of a more appropriate treatment for patients with MIBC,” the authors concluded.

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Heat shock proteins are released in response to various stress factors, including heat, infection, and ischemia and cancer, the researchers explained.