Heat shock protein 105 (Hsp105), a protein overexpressed in a variety of cancers, may be a novel prognostic indicator in patients who have undergone radical cystectomy for muscle-invasive bladder cancer (MIBC), researchers reported.
In a study of bladder cancer samples from 84 patients, Japanese investigators found that high expression of Hsp105 is independently associated with favorable cancer-specific survival (CSS), according to findings published in Molecular and Clinical Oncology (2014;2:38-42). The 5-year CSS for patients was 73.3% for patients with high Hsp105 scores versus 46.9% for those with low Hsp105 scores. CSS was twice as likely among patients with a high hsp105 score as those with a low score. Hsp105 score did not correlate with age, nuclear grade, or pathologic tumor stage.
“The expression of Hsp105 may provide a novel prognostic marker in bladder cancer and enable the selection of a more appropriate treatment for patients with MIBC,” the authors concluded.
Heat shock proteins are released in response to various stress factors, including heat, infection, and ischemia and cancer, the researchers explained.