Merck announced the initial presentation of data on the investigational use of KEYTRUDA® (pembrolizumab), Merck’s anti-PD-1 therapy, in PD-L1 positive, advanced urothelial cancer, otherwise known as bladder cancer. Results from the early findings indicated a confirmed overall 24 percent response rate using KEYTRUDA as monotherapy as measured by RECIST v1.1, central review (n= 7/29: 95% CI, 10.3-43.5) including a complete response rate of 10 percent (3/29).

During the analysis, response durations spanned from 16+ to 40+ weeks with six out of the seven responders continuing on therapy. In the continuing study, 64 percent (61/95) of patients who were screened had tumors that were positive for PD-L1 expression.

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