Men who use finasteride may be at lower risk of bladder cancer than those who do not, according to a new study.

The study included 72,370 men who participated in the Prostate, Lung, Colorectal, and Ovarian cancer screening trial. Bladder cancer was diagnosed in 65 (1.07%) of the 6,069 men who reported using finasteride compared with 966 (1.46%) of the 66,301 men who reported no finasteride use, investigators led by Michael A. Liss, MD, of the University of Texas Health Science Center at San Antonio, reported online ahead of print in European Urology.  After controlling for age and smoking, finasteride use was associated with a significant 36% decreased risk of a bladder cancer diagnosis.

Regarding study limitations, the authors noted that their study was observation and not randomized. In addition, many confounding variables for bladder cancer, such as alcohol use, were not available for analysis.

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