(HealthDay News) — A new study indicates that 8% of patients — or 1 in 12 — already diagnosed with one form of cancer will develop a second unrelated malignancy. The findings were published online in Cancer.

The study included more than 2 million people diagnosed with cancer. Patients in the study were initially diagnosed with cancers of the prostate, breast, lung, colon, rectum, bladder, uterus, or kidney or melanoma or non-Hodgkin lymphoma. Of those who developed a second cancer, only 13% died of their initial cancer, while 55% died of their second primary malignancy.

The team found that patients diagnosed with bladder cancer were the most at risk for developing a second malignancy. Thirty-four percent of bladder cancer patients were diagnosed with a second cancer during the 20-year study. Of those second cancers, 25% were lung cancer cases. People initially diagnosed with non-Hodgkin lymphoma also faced a particularly high risk for a second cancer. The most common second cancers for these patients were lung, prostate, or breast cancers.

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“Lung cancer is a very common and extremely lethal disease, and the national screening trial found [in 2011] CT scans actually saved lives,” study author Karim Chamie, MD, of the David Geffen School of Medicine at University of California, Los Angeles, said in a news release. “We could make a significant improvement in cancer survivorship, for instance, if we monitored bladder cancer patients annually for second, unrelated lung cancers,” he added.

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1. Donin N, Filson C, Drakaki A, et al. Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008. Cancer. 2016 5 July. [Epub ahead of print.] doi:10.1002/cncr.30164.