Cytology and Biomarkers in NMIBC
Cystoscopy and cytology remain the standard for diagnosis, but a plethora of urinary biomarkers could someday be a useful adjunct to NMIBC surveillance.
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Hypothermia During Bladder Cancer Surgery Does Not Affect Survival
Intraoperative hypothermia during radical cystectomy for bladder cancer is not independently associated with either cancer-specific or overall survival, a study found.
Smoking Tied to Worse Bladder Cancer Outcomes After Surgery
Poor outcomes include lower response rate to chemotherapy, higher mortality, recurrence.
Radiation for Abdominal, Pelvic Cancers Ups Secondary Sarcoma Risk
Compared with patients who undergo surgery alone for abdominal or pelvic cancers, those who receive radiation and chemotherapy are at elevated risk for secondary sarcomas.
First-Line Avelumab Maintenance Ups Survival in Urothelial Carcinoma
Avelumab improves overall and progression-free survival among patients with unresectable locally advanced or metastatic urothelial carcinoma whose disease has not progressed while on first-line chemotherapy.
PPI Use Is Negative Prognostic Marker in Urothelial Cancer
PPI use linked to significantly worse progression-free, overall survival in advanced urothelial cancer.
Data Support Ureteroscopy for Upper Tract Urothelial Carcinoma
Patients who underwent ureteroscopic management of low-risk UTUC had a 5-year cancer-specific survival rate of 92.6%.
Acalabrutinib Plus Pembrolizumab Failed to Improve Outcomes in Relapsed mUC
The purpose of this trial was to determine if suppression of MDSCs with acalabrutinib could enhance pembrolizumab activity safely in this population.
Survival Remains Poor in High-Risk Muscle-Invasive Urothelial Carcinoma
Overall and disease-free survival among patients undergoing surgical resection for MIUC is low despite increasing use of neoadjuvant chemotherapy.
MRI Useful for Diagnosing Muscle-Invasive Bladder Cancer
Multiparametric magnetic resonance imaging is highly accurate in differentiating nonmuscle-invasive from muscle-invasive bladder cancer, according to a new systematic review and meta-analysis.
High Long-Term Death Risk From Muscle-Invasive Bladder Cancer Reported
The 20-year mortality rate among patients with muscle-invasive bladder cancer is 71%, according to a study of Swedish patients. Investigators who analyzed a large population-based cohort of patients with bladder cancer that had more than 20 years of follow-up found that muscle-invasive bladder cancer (MIBC) results in a high risk of cancer-specific death, according to…
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