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Novel Gene Therapy Shows Efficacy in BCG-Refractory High-Grade NMIBC

Nadofaragene firadenovec, an adenovirus vector-based gene therapy containing the gene interferon alfa-2b, achieved a complete response in 53% of patients with carcinoma in situ with or without concomitant high-grade Ta or T1 papillary disease at 3 months.
AUA 2017, surgeons, bladder cancer procedure, surgery, cancer diversion

Radical Cystectomy Approaches Offer Similar Long-Term Oncologic Outcomes

Laparoscopic, robotic-assisted, and open radical cystectomy are associated with similar long-term oncologic outcomes among patients with muscle-invasive or high-risk nonmuscle-invasive bladder cancer, according to findings from the CORAL study, the only randomized trial comparing the 3 surgical approaches. In the study, investigators randomly assigned patients with muscle-invasive bladder cancer (MIBC, 38 patients) or high-risk non-muscle…
mri, bladder cancer, mri scan, bladder scan, urology, nephrology, aua 2017

NAC Increases Pathologic Complete Response Rate in High-Risk MIBC

In a study of patients with high-risk muscle-invasive bladder cancer, patients who received cisplatin-based neoadjuvant chemotherapy had a 3.6 times higher rate of pathologic complete response compared with those who had upfront radical cystectomy.

Best Practices for Handling BCG Waste

What is the proper procedure for handling bacillus Calmette-Guerin (BCG) waste? Does the room need to be closed off after instilling the drug into the bladder?
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