Cytology and Biomarkers in NMIBC
Cystoscopy and cytology remain the standard for diagnosis, but a plethora of urinary biomarkers could someday be a useful adjunct to NMIBC surveillance.
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Delayed RC for Histologic Variant Urothelial Bladder Cancer Ups Death Risk
Each 1-month delay in radical cystectomy following diagnosis of variant histology urothelial carcinoma of the bladder was associated with a 36% increased risk of death, a study found.
Robotic, Open Cystectomy for Bladder Cancer Offer Comparable Outcomes
In a propensity score matched analysis, robotic-assisted and open radical cystectomy for urothelial bladder cancer did not differ significantly with respect to disease recurrence and cancer-specific mortality rates.
Combo Shows Promise as Alternative for Metastatic Urothelial Carcinoma
In a phase 2 trial, a regimen of gemcitabine plus eribulin compared favorably with other regimens for the first-line treatment of cisplatin-ineligible patients with metastatic urothelial carcinoma.
UTUC With Isolated Lymph Node Involvement Predicts Poor Survival
Patients who undergo surgical resection of nonmetastatic upper tract urothelial carcinoma with isolated lymph node involvement have a 5-year overall survival rate of only 24%, a study found.
Guideline-Based Hematuria Evaluation May Up Risk of Secondary Cancers
Uniform use of computed tomography for hematuria workups marginally increases detection of urinary tract cancers while raising the risk for secondary cancers from imaging-associated radiation, researchers concluded.
Erdafitinib Achieves 40% Response Rate in Advanced Urothelial Cancers
In a phase 2 trial, erdafitinib demonstrated measurable antitumor activity in 40% of patients with FGFR3-mutant advanced urothelial cancers, investigators reported.
Frailty Predicts Higher In-Hospital Mortality After Radical Cystectomy
Frail patients are more likely than non-frail patients to experience adverse perioperative outcomes after radical cystectomy, a study found.
Bladder Cancer Surgery Outcomes Better Among Statin Users
Study of patients who underwent radical cystectomy for bladder cancer found that those who used statins had improved overall and cancer-specific survival.
Poor Diabetes Control Linked to Worse NMIBC Outcomes
Among patients with non-muscle-invasive bladder cancer, those with diabetes and HbA1c levels below 7% have shorter progression-free survival.
Adverse Events Associated With Outcomes in PD-1/PD-L1–Treated Urothelial Carcinoma
An FDA pooled analysis suggests that certain AEs were associated with response and overall survival in PD-1/PD-L1-treated urothelial cancer.
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