Cytology and Biomarkers in NMIBC
Cystoscopy and cytology remain the standard for diagnosis, but a plethora of urinary biomarkers could someday be a useful adjunct to NMIBC surveillance.
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Novel Gene Therapy Shows Efficacy in BCG-Refractory High-Grade NMIBC
Nadofaragene firadenovec, an adenovirus vector-based gene therapy containing the gene interferon alfa-2b, achieved a complete response in 53% of patients with carcinoma in situ with or without concomitant high-grade Ta or T1 papillary disease at 3 months.
Risk Factors for Reoperation After Radical Cystectomy Identified
Higher body mass index, a history of chronic obstructive pulmonary diseases, and black race are associated with an increased risk of reoperation within 30 days of racial cystectomy, a study found.
Tools for Assessing, Managing Elderly With Cancer for Malnutrition
This review discusses nutritional interventions and management of nutritional status in elderly patients with cancer.
Radical Cystectomy Approaches Offer Similar Long-Term Oncologic Outcomes
Laparoscopic, robotic-assisted, and open radical cystectomy are associated with similar long-term oncologic outcomes among patients with muscle-invasive or high-risk nonmuscle-invasive bladder cancer, according to findings from the CORAL study, the only randomized trial comparing the 3 surgical approaches. In the study, investigators randomly assigned patients with muscle-invasive bladder cancer (MIBC, 38 patients) or high-risk non-muscle…
FDA Labeling Restriction Quickly Reflected in Oncology Practice
FDA label change linked to decrease in immunotherapy use, increases in chemotherapy use, PD-L1 testing
Bladder Cancer Linked to Stewed, Roasted Meat
High intake of stewed or roasted meat, but not boiled, fried, or preserved meat, is associated with increased odds of bladder cancer, a case-control study found.
Immunotherapy + Chemo May Improve Outcomes in Metastatic Urothelial Cancer
First-line treatment with both atezolizumab and platinum-based chemotherapy (PBC) is associated with prolonged progression-free survival vs PBC alone in patients with metastatic urothelial cancer, a study found.
NAC Increases Pathologic Complete Response Rate in High-Risk MIBC
In a study of patients with high-risk muscle-invasive bladder cancer, patients who received cisplatin-based neoadjuvant chemotherapy had a 3.6 times higher rate of pathologic complete response compared with those who had upfront radical cystectomy.
Women Have Lower Relative Survival After Bladder Cancer Diagnosis
In a study, women with bladder cancer had approximately 1.5-fold higher mortality than men — but only in the short term.
Best Practices for Handling BCG Waste
What is the proper procedure for handling bacillus Calmette-Guerin (BCG) waste? Does the room need to be closed off after instilling the drug into the bladder?
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