A history of bariatric surgery is associated with a reduction in the risk of uterine malignancy, while BRCA1 carriers have an increased risk of high-risk uterine cancer, according to two studies presented at the Society of Gynecologic Oncology’s Annual Meeting on Women’s Cancer, held from in Tampa, Fla.

Kirsty Kay Ward, M.D., from the University of California San Diego Moores Cancer Center, and colleagues describe the risk of uterine malignancy among women who have had weight loss surgery.

Data were obtained from 7,431,858 inpatient admissions of women (≥18 years), of whom 103,797 had a history of bariatric surgery and 44,345 had a diagnosis of uterine malignancy. The researchers found that, compared with obese women without a history of bariatric surgery, the relative risk of uterine malignancy was 0.29 for women with a history of bariatric surgery.

Continue Reading

Noah D. Kauff, M.D., from the Memorial Sloan-Kettering Cancer Center in New York City, and colleagues examined the risk of uterine cancer in a cohort of 525 women with BRCA mutations who had undergone risk-reducing salpingo-oophorectomy.

During a median follow-up of 5.8 years, the researchers identified four cases of uterine cancer (2.23 expected; observed/expected, 1.80; P = 0.19). High-risk uterine cancer was observed in four BRCA1 cases, including one woman with no prior breast cancer (0.06 expected; observed/expected, 16.7; P = 0.06) and three with prior breast cancer (0.22 expected; observed/expected, 14.01; P = 0.001).

“Doctors should let their patients with BRCA1 mutations know that this report suggests they may be at risk for rare types of aggressive uterine cancer,” Kauff said in a statement.