The Food and Drug Administration (FDA) has approved Fetroja (cefiderocol; Shionogi) for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis caused by the following susceptible Gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Enterobacter cloacae complex. The treatment is indicated for patients aged ≥18 years with limited or no alternative…
A history of kidney stones among patients undergoing percutaneous coronary intervention is associated with higher in-hospital mortality and 1- and 3-year myocardial infarctions risks.
Next-generation sequencing is being increasingly used to characterize the diversity of T-cell and B-cell receptors in individuals.
The Food and Drug Administration (FDA) has granted Qualified Infectious Disease Product (QIDP) designation and Fast Track designation to ATM-AVI (aztreonam and avibactam; Allergan) for the treatment of complicated intra-abdominal infections (cIAI), complicated urinary tract infections (cUTI), and hospital-acquired bacterial pneumonia (HABP)/ventilator-associated bacterial pneumonia (VABP). Aztreonam is a monobactam that has activity against metallo β-lactamase…
Hazard ratio 0.44 for incident cancer with loss of at least 20 to 35 versus <20% of total body weight.
The highest vs lowest quartile of vitamin D binding protein was associated with 4.1-fold increased odds of renal cell carcinoma in adjusted analyses.
Regardless of PSA levels triggering biopsy, no difference in prostate cancer detection at biopsy.
A high dose and continuous infusion of cefoxitin has been associated with clinical success in treating febrile urinary tract infections in men caused by extended spectrum beta-lactamase–producing E coli.
Variety of ethnicities need to be included in studies of germline testing to better understand variants.
Active surveillance (AS) is an appropriate management strategy for black men with favorable-risk prostate cancer (PCa) who adhere to a standardized protocol of regular PSA tests and biopsies, investigators reported. The prospective, multi-institutional cohort Canary Prostate Cancer Active Surveillance Study (PASS), which included 1315 men on AS, found that black men were at no higher…