Higher levels of uric acid are weakly but significantly associated with progression of kidney disease, according to researchers.


Michel Chonchol, MD, of the University of Colorado Health Sciences Center in Denver, and his colleagues analyzed data from 5,808 participants in the Cardiovascular Health Study. The researchers divided patients into uric acid quintiles: 1 (4.41 mg/dL or less); 2 (4.41-5.20 mg/dL); 3 (5.21-5.90 mg/dL); 4  (5.91-6.90 mg/dL); and 5 (greater than 6.90 mg/dL). Kidney disease progression was defined as a decrease in estimated glomerular filtration rate (GFR) of 3 mL/min/1.73 m2 per year or more (0.05 mL/sec or more).

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The proportion of subjects with CKD—defined as an estimated GFR less than 60 mL/min/1.73 m2—was 7%, 14%, 12,%, 25%, and 42% for quintiles 1, 2, 3, 4, and 5, respectively. The adjusted odds ratio for kidney disease progression was 1.0, 0.88, 1.23, 1.47, and 1.49 for quintiles 1 through 5.


The investigators reported findings in the American Journal of Kidney Diseases (2007;50:239-247).