SAN FRANCISCO—Researchers are concerned about cardiotoxicity associated with sunitinib, a treatment for advanced kidney cancer.


Of 48 assessable patients treated with the drug at Stanford University Comprehensive Cancer Center in Palo Alto, Calif., six (12.5%) experienced grade 3/4 left ventricular dysfunction during treatment, a rate much higher than reported previously, investigators said. All presented with symptoms of heart failure.

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Findings were reported here at the 2008 Genitourinary Cancers Symposium.