CKD patients are at increased risk for peripheral arterial disease (PAD), researchers conclude.
Aaron R. Folsom, MD, of the University of Minnesota in Minneapolis, and his colleagues followed 14,280 middle-aged adults who participated in the Atherosclerosis Risk in Communities (ARIC) study. Subjects were grouped according to whether they had normal kidney function (estimated glomerular filtration rate 90 mL/min per 1.73 m2 or higher), mildly decreased kidney function (60-89 mL/min per 1.73 m2), or stages 3 to 4 CKD (15-59 mL/min per 1.73 m2).

PAD is defined as new-onset of ankle-brachial index less than 0.9, new intermittent claudication, or PAD-related hospital discharges.

During a mean follow-up time of 13.1 years (186,616 person-years), PAD developed in 1,016 participants, Dr. Folsom’s group reported in the Journal of the American Society of Nephrology (2007;18:629-636). The PAD incidence rates per 1000 person-years were 4.7, 4.9, and 8.6 for the patients with normal kidney function, mildly decreased kidney function, and CKD, respectively.

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Compared with subjects who had normal kidney function, subjects with CKD had a 56% increased risk of PAD after adjusting for CVD risk factors, age, gender, and other potential confounders.