PSA density is strongly associated with pathological stage and biochemical-free survival after radical prostatectomy for prostate cancer, researchers conclude. In lower grade prostate cancers (biopsy Gleason score of 6 or less), PSA density is significantly more accurate in predicting extraprostatic extension and biochemical-free recurrence compared with total PSA, according to investigators at The James Buchanan Brady Urological Institute in Baltimore.


The findings, which appear in the Journal of Urology (2008; published online ahead of print), are based on a study of 13,434 men who underwent radical prostatectomy for clinically localized prostate cancer.

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Among patients with a Gleason score of 7, total PSA was more predictive than PSA density for seminal vesicle and lymph node involvement and biochemical-free recurrence.