SAN FRANCISCO—A new study shows that nephron-sparing techniques for treating renal masses smaller than 4 cm are more effective than radical nephrectomy (RN) in preserving renal function.


Ganesh Raj, MD, and his colleagues at the University of Texas Southwestern Medical Center in Dallas studied 242 patients treated for unilateral renal masses smaller than 4 cm.

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The patients had a normal contralateral kidney. Seventy-one patients were treated with RN, 85 with partial nephrectomy (PN), and 86 with radiofrequency ablation (RFA). CKD stage 3 (glomerular filtration rate less than 60 mL/min per 1.73 m2) was 34 times and 11 times more likely to develop with RN when compared with RFA and PN, respectively, the researchers reported.


Findings were reported here at the 2008 Genitourinary Cancers Symposium and published recently in the Journal of Urology (2008;179:75-80).