Intrauterine exposure to mild analgesics can cause congenital cryptorchidism in male offspring, according to a prospective study of 2,297 Danish and Finnish pregnant women who used aspirin, ibuprofen, paracetamol (acetaminophen), and other pain-relievers during pregnancy.

David Møbjerg Kristensen, MD, and colleagues report in Human Reproduction that the Danish cohort demonstrated a dose-dependent association between the pain-relievers and congenital cryptorchidism, particularly when the agents were used during the second trimester and when different analgesics were used simulatenously.

The second-trimester trend was also observed in the Finnish cohort.

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