Bladder perforation during transurethral resection (TUR) of superficial bladder tumors is associated with worse outcomes, investigators reported in the World Journal of Urology (2014;32:1219–1223).

Evi Comploj, MD, of the Central Hospital of Bolzano, Bolzano, Italy, and colleagues studied 565 patients who underwent TUR for non-muscle-invasive bladder cancer. Of these, 37 (6.5%) experienced bladder perforation at the time of tumor resection. The investigators compared these patients (group 1) with the remaining 538 patients who did not have bladder perforation (group 2).

Group 1 had a higher recurrence rate than group 2. For example, group 1 had 23 single recurrences (62.1%) and group 2 had 246 (46.6%).

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Results showed that group 1 had significantly earlier bladder tumor relapses and a higher risk of T-stage progression than group 2.

Perforation was not significantly associated with overall or cancer-specific survival.