Cigarette smoking is associated with a decreased risk of incident gout, particularly among men, according to a new study published online in Rheumatology.

Weiqi Wang, PhD, and Eswar Krishnan, MD, MPH, of Stanford University School of Medicine in Palo Alto, Calif., analyzed 54-year follow-up data (1948-2002) for 2,279 men and 2,785 women who were gout-free at their first assessment as part of the Framingham Heart Study.

The researchers identified 399 incident cases of gout (249 men and 150 women) over 151,058 person-years of observation. In multivariable analyses, cigarette smoking was associated with a 24% decreased risk of incident gout overall, a 32% decreased risk among men, and an 8% decreased risk among women, after adjusting for age, body mass index, alcohol intake, diabetes, hypertension, kidney disease, Drs. Wang and Krishnan reported.

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