A recent analysis of data from 1,255 diabetic hemodialysis (HD) patients found that low levels of homoarginine are a strong risk factor for sudden cardiac death (SCD) and death due to heart failure in this population.

During a median follow-up of four years, low homoarginine concentrations were strongly associated with the presence of congestive heart failure and left ventricular hypertrophy and with increased levels of brain natriuretic peptide.

Patients in the lowest homoarginine quintile had a greater than twofold increased risk of SCD and a more than threefold increased risk of heart failure-related death than did patients in the highest quintile, Christiane Drechsler, MD, of the University of Wurzburg in Wurzburg, Germany and colleagues reported in the European Journal of Heart Failure (2011;13:852-859).

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