Peritoneal dialysis (PD) may lower glutamate levels released into the brain during ischemic stroke, minimizing tissue damage, according to study involving rats.
Rats administered PD 2.5 hours after being subjected to permanent middle cerebral artery occlusion had significantly smaller increases in plasma glutamate induced by ischemia.
The decrease in plasma glutamate levels was associated with a significant 12.1% reduction in the volume of cerebral infarct, José Sánchez-Prieto, PhD, of Universidad Complutense in Madrid, and colleagues reported online in The Journal of Clinical Investigation.
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