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News in Brief

Gene for Increased Calcium Absorption Raises PCa Risk

After examining vitamin D receptor (VDR) Cdx2 genotype and calcium intake in 533 African-American men with prostate cancer (PCa) and 250 control subjects, Gary G. Schwartz, PhD, and colleagues found that men in the highest quartile of calcium intake had a 2.2 times increased risk of localized and advanced PCa compared with men in the lowest quartile.

Invasive GFR Test Not Better than eGFR

Estimated glomerular filtration rate (eGFR) is linked just as tightly to chronic kidney disease (CKD) complications as the more invasive and cumbersome iothalamate GFR (iGFR) test in a recent study, results that challenges the conventional view that iGFR is the gold-standard measure of kidney function.

Tacrolimus/MMF Regimen Cuts Acute Rejection Rate

In a long-term randomized trial of 150 kidney transplant recipients with a median follow-up of eight years post-transplant, those undergoing immunosuppressive therapy with tacrolimus/mycophenolate mofetil (MMF) experienced significantly less frequent acute rejection (12%) than those treated with tacrolimus/sirolimus (30%) or cyclosporine/sirolimus (28%).

Urine Test Improves PCa Prediction

Testing for the genetic anomaly TMPRSS2:ERG in conjunction with use prostate cancer antigen 3 (PCA3) is better at predicting the presence of prostate cancer (PCa) than either marker alone, according to a report in Science Translational Medicine.

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