Min-Shen Chung, MD, of Chang Gung University College of Medicine in Kaohsiung, Taiwan, and colleagues studied 1,301 type 2 diabetics, of whom 59.6% had nocturia (2 or more voids per night) and 25.3% had severe nocturia (3 or more voids per night).
OAB was associated with a significant 2.2 times increased risk of nocturia after adjusting for age and diabetes duration. Severe nocturia increased the risk of death nearly twofold independent of age and diabetes duration. Patients with severe nocturia had a higher mortality rate compared with those who did not have severe nocturia (6.1% vs. 2.4%).
Other risk factors for nocturia and severe nocturia included stroke, hypertension, calcium channel blocker use, higher serum creatinine level, after adjusting for age, diabetes duration, and presence of OAB.
Male gender, higher estimated glomerular filtration rate, hemoglobin levels, and serum albumin were associated with a lower risk of nocturia.