Patients with gout experienced no clinically significant urate-lowering effects from an 8-week course of a modest dosage of vitamin C (500 mg/day), despite the fact that plasma ascorbate levels increased, according to study findings published in Arthritis & Rheumatism (2013;65:1636-1642).

The study included 40 gout patients. Of these, 20 were randomized to receive an increased dose of allopurinol or to start taking vitamin C, and 20 were randomized to start treatment with allopurinol (100 m/day) or vitamin C.

Researchers observed no significant difference in serum urate or renal function between those who received vitamin C and those who did not.

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