Survivors of childhood cancer are at risk for premature chronic renal failure as their glomerular function continues to deteriorate, according to a study of 1,122 childhood-cancer survivors aged 18 years and older.

After a median follow-up of 21 years after cancer diagnosis, glomerular function deteriorated over time in all subjects, particularly those treated with higher doses of cisplatin, researchers reported in Cancer Epidemiology, Biomarkers & Prevention (2013;22:1736-1746).

Cisplatin, ifosfamide, and nephrectomy were associated with worse glomerular function that persisted during the entire follow-up period. Survivors treated with potentially nephrotoxic medications had a significantly lower glomerular filration rate and higher glomerular dysfunction probability up to 35 years after cancer diagnosis compared with survivors who did not undergo nephrotoxic therapy.

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