Estimated glomerular filtration rate (eGFR) is linked just as tightly to chronic kidney disease (CKD) complications as the more invasive and cumbersome iothalamate GFR (iGFR) test in a recent study, results that challenges the conventional view that iGFR is the gold-standard measure of kidney function.

In 1,214 participants in the Chronic Renal Insufficiency Cohort (CRIC) study, neither iGFR nor eGFR estimated from serum creatinine or from cystatin C strongly associated with CKD complications, according to a report in the Journal of the American Society of Nephrology (2011;22:1931-1937).