Lifestyle- or statin-driven modifications in cardiovascular (CV) risk factors improved sexual function in men with erectile dysfunction (ED), according to a meta-analysis of six trials lasting 12-104 weeks and involving 740 men (mean age 55.4 years).

Bhanu P.Gupta, MD, and associates found, for example, that 12-week use of atorvastatin improved International Index of Erectile Dysfunction (IIEF-5) scores by 7.8 points in one study and by 3.5 points in another. CV risk factor reduction improved ED even in men who were not responsive to PDE-5 inhibitors, researchers reported online in Archives of Internal Medicine.